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Are your patients with GAD

WIRED FOR WORRY?

Symptoms of generalized anxiety disorder (GAD) extend beyond persistent worry and may reflect underlying neurobiological dysregulation.1-3

Explore the neurobiology

Dysregulated connections between key brain regions may underlie the debilitating symptoms that disrupt your patients' daily lives.1,4,5

GAD-7, Generalized Anxiety Disorder 7-Item.

References

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  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed, text rev. American Psychiatric Association; 2022.
  2. Makovac E, Meeten F, Watson DR, et al. Alterations in amygdala-prefrontal functional connectivity account for excessive worry and autonomic dysregulation in generalized anxiety disorder. Biol Psychiatry. 2016;80(10):786-795.
  3. Makovac E, Watson DR, Meeten F, et al. Amygdala functional connectivity as a longitudinal biomarker of symptom changes in generalized anxiety. Soc Cogn Affect Neurosci. 2016;11(11):1719-1728.
  4. Kenwood MM, Kalin NH, Barbas H. The prefrontal cortex, pathological anxiety, and anxiety disorders. Neuropsychopharmacology. 2022;47(1):260-275.
  5. Kolesar TA, Bilevicius E, Wilson AD, Kornelsen J. Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging. Neuroimage Clin. 2019;24:102016.
  6. Forand NR, Nettiksimmons J, Brownell A, et al. The impact of measurement based care at scale: examining the effects of implementation on patient outcomes and provider behaviors. Front Health Serv. 2025;5:1659238.
  7. Spitzer RL, Kroenke K, Williams JBW, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092-1097.
  8. Munir S, Takov V. Generalized anxiety disorder. StatPearls [Internet]. StatPearls Publishing; 2026-. Updated October 17, 2022. Accessed March 19, 2025.